| SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. | breast,lung, |
| SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer. | colorectal, |
| Our data indicate that SLIT2 is frequently inactivated by promoter region CpG island hypermethylation in gliomas and may be a good candidate for a glioma tumour suppressor gene (TSG) located at 4p15.2. | glioma, |
| Deletions in chromosome 4 differentially associated with the development of cervical cancer: evidence of slit2 as a candidate tumor suppressor gene. | cervical, |
| Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation. | breast, |
| Slit2 inhibits tumor growth and metastasis of fibrosarcoma and squamous cell carcinoma and its effect on cell cycle and apoptosis signal pathways is an important mechanism for Slit2-mediated tumor suppression | fibrosarcoma, |
| Slit2 is downregulated in renal cell carcinoma and may have a role as a tumor suppressor | kidney, |
| Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer. | breast, |
| Study demonstrated a role for Slit2 as a tumor suppressor of papillary thyroid cancer (PTC). Slit2 suppressed thyroid cancer cell proliferation, migration, and invasion. Loss of Slit2 expression was associated with poor prognostic factors, such as lymphovascular invasion, cervical LN metastasis, distant metastasis, advanced stage, and recurrence in PTC. | cervical,thyroid, |