| klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer | breast, |
| our results suggest that klotho is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in colorectal cancer | colorectal, |
| KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. | pancreatic, |
| These results indicate Klotho acts as a tumor suppressor during renal cell carcinoma progression | kidney, |
| Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure-Function Analysis | breast, |
| Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma | lymphoma, |
| Klotho was demonstrated to act as a potent tumor suppressor in human ovarian cancer cells. Reduced Klotho expression was detected in the specimens of patients with ovarian cancer, and overexpression of Klotho significantly inhibited cell proliferation of human ovarian cancer cells. | ovarian, |
| Forced expression of Klotho resulted in decline of activation of IGF-1R signaling, accompanied by decreased phosphorylation of its downstream targets, including AKT and ERK1/2. These data indicated that Klotho acts as a tumor suppressor via inhibiting IGF-1R signaling, thus suppressing the viability and promoting apoptosis in Tcell lymphoma. | lymphoma, |
| Our data indicate klotho KL1 as a regulator of metabolic activity in breast cancer and suggest that metabolic alterations underlie KL1 tumor suppressor activities. | breast, |
| Inactivating mutations of tumor suppressor genes KLOTHO and DTWD1 in colorectal cancers | colorectal, |