| NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors | breast, |
| the tumour suppressor activity of NHERF1 in breast may be related to its regulatory effect on the cell cycle to suppress cell proliferation. | breast, |
| Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. | None |
| EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity. | None |
| Findings define a tumor suppressor role for NHERF1 at the plasma membrane, and reveal a novel mechanism for PI3K/Akt activation through PTEN inactivation caused by a loss of membrane-localized NHERF1. | None |
| show for the first time a significant disruption of all three members of the PTEN-NHERF1-PHLPP1 tumor suppressor network in high-grade tumors, correlating with Akt activation and patient_s abysmal survival | None |
| Our results suggest that EBP50 may function as a potential tumor suppressor | None |
| Wild-type NHERF1 acts as a tumour suppressor, while NHERF1 A190D mutation abolishes the tumour-suppressive effect in cancer cells, due to A190D mutation-mediated nuclear NHERF1 translocation and induction of YAP phosphorylation. | None |
| Results suggest the oncogenic role of NHERF1 and promote nuclear NHERF1 as a potential new biomarker of advanced colorectal cancer (CRC). | colorectal, |