Sentence and cancer type
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Cancertype
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation
breast
APOBEC3B mutagenesis in cancer
cervical, bladder, lung, head and neck, breast
These data link oncogene, loss of tumour suppressor gene and drug-induced replication stress with APOBEC3B activity, providing new insights into how cytidine deaminase-induced mutagenesis might be activated in tumourigenesis and limited therapeutically.
unknown
APOBEC3B is a potential factor contributing to suppression of tumor growth in human hepatocellular carcinoma.
liver