| The high frequency of methylation of the CDH1 gene promoter suggests that the inactivation of tumor suppressor genes and of the genes related to the control of cellular proliferation through this mechanism is involved in gallbladder carcinogenesis. | bladder, |
| E-cadherin pathway is a novel and functionally important mediator by which changes in Kruppel-like KLF6 tumor suppressor can directly alter ovarian tumor invasion and metastasis. | ovarian, |
| The transgenic adenocarcinoma of mouse prostate model encompasses androgen depletion independent sublines with increased tumorigenicity and invasiveness. All showed downregulation in tumor suppressor, E-cadherin, and metastatis suppressor, KAI-1. | prostate, |
| Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. | testicular, |
| E-cadherin expression promotes growth of primary breast tumors and conceivably the formation of metastases, supporting a role for MET in metastasis. E-cadherin needs to be reevaluated as a tumor suppressor. | breast, |
| More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis | lung, |
| alpha-catenin represents a bona fide tumor suppressor for the development of lobular-type breast cancer and as such provides an alternative event to E-cadherin inactivation, adherens junction dysfunction, and subsequent constitutive actomyosin contraction. | breast, |
| It is a tumor suppressor gene and can be used as a biomarker to assess and evaluate the progression and prognosis of oral dysplastic lesions and oral squamous cell carcinoma. | oral |
| Methylation of tumour suppressor genes RUNX3, RASSF1A and E-Cadherin in HCV-related liver cirrhosis and hepatocellular carcinoma. | liver, |
| inactivation of Cdh1 and Cdh5 is likely to cooperate with the loss of p53, suggesting a possible tumor suppressive function of these genes in mammary carcinogenesis | None |
| in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion | None |
| increased E-cadherin and alpha-catenin expression and reduced Wnt signaling might be involved in the mechanisms of tumor suppressor function of BCSC-1. | None |
| Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction. | None |
| GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. | None |
| The tumor-suppressor function of E-cadherin. | None |
| Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and beta-catenin/Tcf-4 signaling. | colorectal, |
| Key roles of ZEB1 and E-cadherin in the oncogenesis and invasiveness of lung squamous cell carcinoma. | lung, |
| Our results establish that the E-cadherin ectodomain-specific mAb DECMA-1 inhibits Ecad(+)/HER2(+) breast cancers by hindering tumor growth and inducing apoptosis via downregulation of key oncogenic pathways | breast, |
| Deletion of Cdh1 in prostatic luminal epithelial cells in transgenic mice induced the development of prostatic intraepithelial neoplasia (PIN). Study provides novel evidence demonstrating a comprehensive role of Cdh1 in maintaining epithelial integrity during prostate oncogenic transformation, tumor initiation and progression. | prostate, |
| elevation of E-cadherin, a cell adhesion molecule and suppression of beta-catenin, a proto-oncogene have been observed in presence of CaSR agonists whereas reverse effect has been seen in presence of CaSR antagonist | None |