Sentences
Showing 1-20 of 159 items.
| PubMed | Sentence | Cancertype | Gene ID |
|---|---|---|---|
| 28122586 | miR-182 reveals its oncogenic capacity in medullary thyroid carcinoma by directly contributing to the invasive behavior through loss of the tumor suppressive HES1/Notch1 signaling circuit. | thyroid, | 406958 |
| 12590261 | Notch1 functions as a tumor suppressor in mouse skin. | skin, | 4851 |
| 18633435 | arsenite, by decreasing generation of the tumor suppressor Notch1, contributes to skin carcinogenesis | skin, | 4851 |
| 18758480 | Notch signaling, and more specifically Notch1, acts as a tumor suppressor in mouse skin. Review. | skin, | 4851 |
| 19799080 | Notch1 signal activation can inhibit the proliferation and neuroendocrine marker expression in small cell lung cancer cells, and may behave as a tumor suppressor. | lung, | 4851 |
| 21798897 | identified mutations in FBXW7 and NOTCH in head and neck squamous cell carcinoma; nearly 40% of mutations in NOTCH1 predicted to truncate the gene product, suggesting NOTCH1 may function as tumor suppressor gene rather than oncogene in this tumor type | HNSC, | 4851 |
| 24801890 | Sustained Notch1 expression is one key event implicated in the arsenite human skin carcinogenic effect, also provides mechanistic insights into the molecular aspects that determine whether Notch signaling will be oncogenic or tumor suppressive. | skin, | 4851 |
| 25574842 | results indicate that NOTCH serves as a tumor suppressor in the bladder and that loss of this pathway promotes mesenchymal and invasive features. | bladder, | 4851 |
| 26294213 | HPV-positive oral tumors with an activated Notch1 allele had high cell proliferation and tumor growth rates. Notch1 loss sped invasive tumor growth. Though Notch1 is a tumor suppressor in mouse skin, oncogenes perturbing Notch1 expression promoted tumors. | skin, | 4851 |
| 26682927 | The cKO mice showed susceptibility to esophageal tumorigenesis, underscoring Notch1 as a tumor suppressor. | esophageal, | 4851 |
| 28122586 | miR-182 reveals its oncogenic capacity in medullary thyroid carcinoma by directly contributing to the invasive behavior through loss of the tumor suppressive HES1/Notch1 signaling circuit. | thyroid, | 4851 |
| 29643502 | Review of the roles of NOTCH1 and NOTCH2 in urinary bladder cancer suggests that NOTCH1 acts as a tumor suppressor and NOTCH2 acts as an oncogene that promotes cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle progression, and maintenance of stemness. | bladder, | 4851 |
| 30389219 | The tumour suppressor role of Notch1 was supported and the use of Notch1 agonists may have a role in improving the prognosis of hepatocellular carcinoma (HCC). | liver, | 4851 |
| 30408569 | Our findings extend the results of prior loss of function and mutation studies and importantly show that NOTCH1 has a tumor suppressor role in LUSC that is independent of mutations. | lung, | 4851 |
| 17344417 | findings report that the Notch1 gene is a p53 target in human keratinocytes with a role in tumor suppression of this cell type through negative regulation of the ROCK1/2 and MRCKalpha kinases | None | 4851 |
| 17353266 | Data demonstrate a novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress and suggest a novel tumor suppressor mechanism of p53 in the development of HPV-induced tumors. | None | 4851 |
| 18192969 | in UV-related squamous cell photocarcinogenesis Notch 1 downregulation could mirror a tumor suppressor function of the receptor, in sun-protected squamous cell carcinomas Notch 1 was upregulated | None | 4851 |
| 18758480 | Notch 1 is a tumor suppressor gene under direct p53 control. Review. | None | 4851 |
| 19573812 | In the, Notch1 deletion leads to tumor formation, suggesting that Notch1 is a tumor suppressor within this context. | None | 4851 |
| 20484026 | Loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC. | None | 4851 |