Sentences

Showing 21-40 of 159 items.
PubMedSentenceCancertypeGene ID
21427293Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.None4851
27176495We found that VPA induced proliferation suppression, cell apoptosis and cell cycle arrest in all tested cell lines, with an increase of Notch1 active form ICN1 as a tumor suppressorNone4851
31712410Notch1 pathway role in the mutant p53 regulation of p63/p73 transcriptional program during tumor suppression.None4851
15472075more than 50% of T cell acute lymphoblastic leukemias, including tumors from all major molecular oncogenic subtypes, have activating mutations involving the extracellular heterodimerization domain and/or the C-terminal PEST domain of NOTCH1leukemia,4851
16887975Transgenic intracellular Notch1 and C-terminal-deleted Notch1 mutant molecules behave collaboratively as oncogenes for T cells; these mice may represent relevant models of human T-cell leukemias.leukemia,4851
18765521Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. lymphoma,leukemia,4851
19771395The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo. glioma,4851
19771395These results suggest that Notch1 plays an important oncogenic role in the development and progression of astrocytic gliomas.glioma,4851
19953094RhoC is an effector of Notch1 in cervical carcinoma cells. There is a pro-oncogenic role of Notch signalling in human cervical cancers.cervical,4851
20829372Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient mice is associated with T-cell acute lymphoblastic leukemias.leukemia,4851
20965628This review is an update on the current understanding of the molecular basis of T-cell acute lymphoblastic leukemia, with a particular focus on the role of the NOTCH1 oncogene.leukemia,4851
21679465NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. breast,4851
21798897identified mutations in FBXW7 and NOTCH in head and neck squamous cell carcinoma; nearly 40% of mutations in NOTCH1 predicted to truncate the gene product, suggesting NOTCH1 may function as tumor suppressor gene rather than oncogene in this tumor typeHNSC,4851
22237151study reports presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode components of the Polycomb repressive complex 2 (PRC2), in 25% of T cell acute lymphoblastic leukemias; study suggesst tumor suppressor role for PRC2 in leukemia and suggest a gnized dynamic interplay between oncogenic NOTCH1 and PRC2leukemia,4851
22673746Aberrant and constitutively active NOTCH1 signaling triggered by activating mutations in the NOTCH1 gene contributes to oncogenic transformation and is a hallmark of T-cell acute lymphoblastic leukemia. (Review)leukemia,4851
22781569NOTCH1 gene may function as an oncogene by regulating HES1/PTEN in invasive bladder transitional cell carcinoma, and its aberrant activation promotes cell proliferation.bladder,4851
22986536Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells. liver,4851
23108395DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia. leukemia,4851
23307033The viral oncogene Np9 acts as a critical molecular switch for co-activating beta-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. leukemia,4851
23791182Missense FBXW7 mutations are prevalent in various tumors, including T cell acute lymphoblastic leukemia; study shows that these mutations specifically bolster cancer-initiating cell activity in collaboration with Notch1 oncogenes but spare normal hematopoietic stem cell function.leukemia,4851