Sentences
Showing 61-80 of 159 items.
| PubMed | Sentence | Cancertype | Gene ID |
|---|---|---|---|
| 22510873 | the spectrum of oncogenic lesions activating NOTCH1 signaling in human T-ALL. | None | 4851 |
| 23022380 | NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. | None | 4851 |
| 24309677 | Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. | None | 4851 |
| 24726647 | These results indicate that Notch1 signaling in human hematopoietic stem cells promotes CD8(+) single posistive T cell development, and that T cell leukemogenesis may require additional oncogenic factors other than Notch1 activation. | None | 4851 |
| 26400206 | Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. | None | 4851 |
| 27872499 | study identified a critical role for PRL2 phosphatase in the proliferation and survival of human T-ALL cells; demonstrated that PRL2 is important for the leukemogenic potential of oncogenic NOTCH1 in vivo | None | 4851 |
| 28143869 | Our findings demonstrate Hsp90 blockade leads to ICN1 destabilization, providing an alternative strategy to antagonize oncogenic Notch1 signaling with Hsp90-selective inhibitors | None | 4851 |
| 28791383 | This study indicates that NOTCH1 acts as an oncogene and that the NOTCH1 mutation (p.A465T) in the ligand-binding region causes the loss of tumorigenicity by downregulating the NOTCH1 pathway | None | 4851 |
| 30967635 | Chloroquine (CQ) impairs the redox balance, induces ds DNA breaks and activates the DNA damage response. CQ also interferes with intracellular trafficking and processing of oncogenic NOTCH1 | None | 4851 |
| 9111040 | Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. | None | 4851 |
| 27431799 | Reduced NOTCH3/NICD3 and NOTCH4/NICD4 in miR-96- and miR-183-expressing nasopharyngeal carcinoma (NPC) cells suggest the involvement of the NOTCH signaling pathway in their tumor suppressive function. | nasopharyngeal,laryngeal, | 4855 |
| 10797286 | Expression of an activated Notch4(int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro. | None | 4855 |
| 8681805 | Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. | None | 4855 |
| 9168133 | Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3. | None | 4855 |
| 9189758 | Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis. | None | 4855 |
| 24141420 | These findings support an important role of p27 in Notch1-dependent oncogenic signaling. | None | 1027 |
| 23220650 | p53-induced miR-107 suppresses brain tumor cell growth and down-regulates CDK6 and Notch-2 expression, supporting its tumor suppressor role and utility as a target for glioma therapy. | brain,glioma, | 406901 |
| 27431799 | Reduced NOTCH3/NICD3 and NOTCH4/NICD4 in miR-96- and miR-183-expressing nasopharyngeal carcinoma (NPC) cells suggest the involvement of the NOTCH signaling pathway in their tumor suppressive function. | nasopharyngeal,laryngeal, | 4854 |
| 23610446 | Results reveal a novel function of Notch3 in senescence regulation and tumor suppression. | None | 4854 |
| 32570839 | Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL | None | 4854 |