Sentences

Showing 81-100 of 159 items.
PubMedSentenceCancertypeGene ID
16186803activated Notch3 can function as an oncogene in the developing brain, and link the Notch pathway to human choroid plexus tumor pathogenesisbrain,4854
33931470Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis.unknown29126
28486549p53 tumor suppressor pathway was downregulated as demonstrated by both aCGH and RNA-seq analysis. Notch, EGFR, NRAS, and RB1 pathways were also significantly dysregulated in tumors compared with normal liver tissueliver,7157
17353266Data demonstrate a novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress and suggest a novel tumor suppressor mechanism of p53 in the development of HPV-induced tumors.None7157
18757425data link EWS-FLI1 to the NOTCH and p53 pathways and provide a plausible basis both for NOTCH tumor suppressor effects and oncogenesis of cancers that retain wild-type p53None7157
19751190Studies indicate that MAML1 functions as a coactivator for the tumor suppressor p53, MEF2C, beta-catenin and Notch signaling.None7157
23034333The pleiotropic nature of miRNA-10b was due to its suppression of multiple tumor suppressors, including TP53, FOXO3, CYLD, PAX6, PTCH1, HOXD10 and NOTCH1.None7157
26877611Report a simple, non-germline murine intrahepatic cholangiocarcinoma model with activated Notch, loss of p53 and IDH1R132C mutation, supporting the oncogenic potential of IDH1R132C.liver,cholangiocarcinoma,3417
22237151study reports presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode components of the Polycomb repressive complex 2 (PRC2), in 25% of T cell acute lymphoblastic leukemias; study suggesst tumor suppressor role for PRC2 in leukemia and suggest a gnized dynamic interplay between oncogenic NOTCH1 and PRC2leukemia,23512
22237151studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 functionleukemia,23512
21637926Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling.liver,864
19074836Notch inhibits expression of the Kr??ppel-like factor 4 tumor suppressor in the intestinal epithelium.None9314
26400206arcinol treatment led to the upregulation of several tumor suppressor microRNAs, and miR-200c increased by garcinol treatment was found to target and downregulate Notch1None406985
29444743Tumor-Suppressive MicroRNA-708 Targets Notch1 to Suppress Cell Proliferation and Invasion in Gastric Cancergastric,100126333
19765378[The OTT-MAL fusion oncogene: another Notch in megakaryoblastic leukemia]. leukemia,64783
23040356BCL11B, FLT3, NOTCH1 and FBXW7 mutation status in T-cell acute lymphoblastic leukemia patients. leukemia,64919
25574842results indicate that NOTCH serves as a tumor suppressor in the bladder and that loss of this pathway promotes mesenchymal and invasive features.bladder,4853
26769750NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through epithelial-to-mesenchymal transition, cell-cycle progression, and maintenance of stemness. Inhibition of NOTCH2 is a rational novel treatment strategy for invasive bladder cancer.bladder,4853
29643502Review of the roles of NOTCH1 and NOTCH2 in urinary bladder cancer suggests that NOTCH1 acts as a tumor suppressor and NOTCH2 acts as an oncogene that promotes cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle progression, and maintenance of stemness.bladder,4853
28745938NEDD4 exerts its oncogenic function partly due to regulation of PTEN and Notch-1 in bladder cancer cells.bladder,4734